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Research Identifies 3 Genes Possibly Linked to Chronic Back Pain

Does it seem like some people are more prone to chronic back pain than others? Recent research suggests there could be a reason for this. A recent study identified three genes possibly linked to chronic back pain.

genes possibly linked to chronic back pain

Researchers studied the DNA of over 150,000 adults of European ethnicity. Some reported chronic back pain, others did not. After taking into account sex, BMI, and other variables, the researchers found statistical evidence linking three different genes to the individuals with chronic back pain.

DNA researchers believe the SOX5 gene provides instruction for the body’s cartilage growth (among other things). This study showed a correlation between the SOX5 gene and individuals with lumbar inter-vertebral disc degeneration.

Another gene identified in the study is called CCDC26/GSDMC. Individuals with specific variants of this gene were more prone to chronic back pain due to osteoarthritis, cartilage related problems and disc herniations.

The third gene identified is called DCC. Researchers are unsure of how this gene affects chronic back pain. One theory is that it is affects the pain receptors in the spine. However, this gene is also sometimes linked to individuals’ depression. Scientists are aware of a link between depression and chronic pain.  This relationship could also explain the connection between this gene and chronic back pain.

Advancements in science and technology have been assisting us for decades in dealing with conditions of the spine. Learning more about the root cause of spinal conditions could push these medical advancements even farther. At the very least, they could answer the question, why do I have so much back pain?

Source: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007601

*Please Note: Information on this site or any recommended sites should not be used as a diagnosis or a substitute for talking with your doctor. Always talk with your doctor about diagnosis and treatment information.
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